InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ghsr

Summary

InnateDB Gene

IDBG-134399.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ghsr

Gene Name

growth hormone secretagogue receptor

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000051136

Encoded Proteins

IDBP-134401

growth hormone secretagogue receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121853:
This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:27371351-27378010

Strand

Forward strand

Band

Transcripts

ENSMUST00000057186

ENSMUSP00000061153

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001616	growth hormone secretagogue receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016520	growth hormone-releasing hormone receptor activity
GO:0017046	peptide hormone binding
GO:0042562	hormone binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0008154	actin polymerization or depolymerization
GO:0008343	adult feeding behavior
GO:0009725	response to hormone
GO:0009755	hormone-mediated signaling pathway
GO:0030252	growth hormone secretion
GO:0032094	response to food
GO:0032100	positive regulation of appetite
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032869	cellular response to insulin stimulus
GO:0040018	positive regulation of multicellular organism growth
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process
GO:0043134	regulation of hindgut contraction
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0045923	positive regulation of fatty acid metabolic process
GO:0046676	negative regulation of insulin secretion
GO:0046697	decidualization
GO:0050728	negative regulation of inflammatory response
GO:0051963	regulation of synapse assembly