InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Apc

Summary

InnateDB Gene

IDBG-134573.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Apc

Gene Name

adenomatosis polyposis coli

Synonyms

AI047805; AU020952; AW124434; CC1; mAPC; Min

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005871

Encoded Proteins

IDBP-134575	adenomatosis polyposis coli
IDBP-134577	adenomatosis polyposis coli
IDBP-248875	adenomatosis polyposis coli
IDBP-621763	adenomatosis polyposis coli
IDBP-621770	adenomatosis polyposis coli
IDBP-621772	adenomatosis polyposis coli

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134982:
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18: 34220924-34322189

Strand

Forward strand

Band

Transcripts

ENSMUST00000079362	ENSMUSP00000078337
ENSMUST00000066133	ENSMUSP00000064214
ENSMUST00000115781	ENSMUSP00000111447
ENSMUST00000171187	ENSMUSP00000127131
ENSMUST00000170023
ENSMUST00000163295	ENSMUSP00000129095
ENSMUST00000170195
ENSMUST00000165590	ENSMUSP00000128327
ENSMUST00000167136

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 115 interaction(s) predicted by orthology.

Experimentally validated
Total	51	[view]
Protein‑Protein	19	[view]
Protein‑DNA	0
Protein‑RNA	0
DNA-DNA	32	[view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	115 [view]

Gene Ontology

Accession

GO Term

Molecular Function

GO:0005488	binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008017	microtubule binding
GO:0019887	protein kinase regulator activity
GO:0019901	protein kinase binding
GO:0045295	gamma-catenin binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0000281	cytokinesis after mitosis
GO:0001822	kidney development
GO:0001942	hair follicle development
GO:0006461	protein complex assembly
GO:0006974	response to DNA damage stimulus
GO:0007026	negative regulation of microtubule depolymerization
GO:0007050	cell cycle arrest
GO:0007091	mitotic metaphase/anaphase transition
GO:0007094	mitotic cell cycle spindle assembly checkpoint
GO:0007163	establishment or maintenance of cell polarity
GO:0007389	pattern specification process
GO:0007409	axonogenesis
GO:0008285	negative regulation of cell proliferation
GO:0009798	axis specification
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0009954	proximal/distal pattern formation
GO:0016055	Wnt receptor signaling pathway
GO:0016477	cell migration
GO:0019827	stem cell maintenance
GO:0030178	negative regulation of Wnt receptor signaling pathway
GO:0030334	regulation of cell migration
GO:0030335	positive regulation of cell migration
GO:0030856	regulation of epithelial cell differentiation
GO:0030858	positive regulation of epithelial cell differentiation
GO:0031016	pancreas development
GO:0031116	positive regulation of microtubule polymerization
GO:0031122	cytoplasmic microtubule organization
GO:0031274	positive regulation of pseudopodium assembly
GO:0032886	regulation of microtubule-based process
GO:0033077	T cell differentiation in thymus
GO:0035019	somatic stem cell maintenance
GO:0042483	negative regulation of odontogenesis
GO:0042493	response to drug
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043409	negative regulation of MAPK cascade
GO:0043588	skin development
GO:0045595	regulation of cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0045667	regulation of osteoblast differentiation
GO:0045670	regulation of osteoclast differentiation
GO:0045732	positive regulation of protein catabolic process
GO:0045736	negative regulation of cyclin-dependent protein kinase activity
GO:0045785	positive regulation of cell adhesion
GO:0046716	muscle cell homeostasis
GO:0048538	thymus development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051171	regulation of nitrogen compound metabolic process
GO:0051276	chromosome organization
GO:0051726	regulation of cell cycle
GO:0051781	positive regulation of cell division
GO:0051988	regulation of attachment of spindle microtubules to kinetochore
GO:0060041	retina development in camera-type eye
GO:0060070	canonical Wnt receptor signaling pathway
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway

Cellular Component

GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005881	cytoplasmic microtubule
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0005923	tight junction
GO:0016328	lateral plasma membrane
GO:0030027	lamellipodium
GO:0030426	growth cone
GO:0030877	beta-catenin destruction complex
GO:0031253	cell projection membrane
GO:0032587	ruffle membrane
GO:0033267	axon part
GO:0035371	microtubule plus end
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0044295	axonal growth cone
GO:0045202	synapse

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID	Gene Order	Method	Confidence	Comments
ENSG00000134982		Ortholuge	SSD Ortholog	Ortholog supports species divergence
ENSBTAG00000018852	Not yet available	Ortholuge	SSD Ortholog	Ortholog supports species divergence