Version 5.4
Mus musculus Gene: Msc
Summary
InnateDB Gene IDBG-134646.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Msc
Gene Name musculin
Synonyms bHLHa22; MyoR
Species Mus musculus
Ensembl Gene ENSMUSG00000025930
Encoded Proteins
IDBP-134648
musculin
IDBP-789829
musculin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178860:
The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:14753346-14755992
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000027062 ENSMUSP00000027062
ENSMUST00000190719 ENSMUSP00000140741
ENSMUST00000188982
ENSMUST00000190471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001206 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0014707 branchiomeric skeletal muscle development
GO:0060021 palate development
GO:0060539 diaphragm development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178860
View Gene Order
ENSBTAG00000005404
Not yet available
Cross-References
SwissProt O88940
TrEMBL
UniProt Splice Variant
Entrez Gene 17681
UniGene Mm.5820
RefSeq NM_010827
OMIM
CCDS CCDS14825
HPRD
IMGT
MGI ID MGI:1333884
MGI Symbol Msc
EMBL AF087035 AF108216 BC103592 BC103593 BC103594 BC103623
GenPept AAC69869 AAD10053 AAI03593 AAI03594 AAI03595 AAI03624
RNA Seq Atlas 17681

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca