InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arl2

Summary

InnateDB Gene

IDBG-134695.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arl2

Gene Name

ADP-ribosylation factor-like 2

Synonyms

2610009M23Rik; AI115441; AW553335

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024944

Encoded Proteins

IDBP-134697

ADP-ribosylation factor-like 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213465:
This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:6134374-6141406

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025893	ENSMUSP00000025893
ENSMUST00000134821
ENSMUST00000123193

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0019003	GDP binding
GO:0031683	G-protein beta/gamma-subunit complex binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0007049	cell cycle
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0010811	positive regulation of cell-substrate adhesion
GO:0015031	protein transport
GO:0031113	regulation of microtubule polymerization
GO:0031116	positive regulation of microtubule polymerization
GO:0034260	negative regulation of GTPase activity
GO:0051297	centrosome organization
GO:0051457	maintenance of protein location in nucleus
GO:0070830	tight junction assembly

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005758	mitochondrial intermembrane space
GO:0005813	centrosome
GO:0016328	lateral plasma membrane
GO:0070062	extracellular vesicular exosome