Mus musculus Gene: Abcc1
Summary
InnateDB Gene IDBG-135084.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Abcc1
Gene Name ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Synonyms Abcc1a; Abcc1b; Mdrap; MRP; Mrp1;
Species Mus musculus
Ensembl Gene ENSMUSG00000023088
Encoded Proteins
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Protein Structure
Entrez Gene
Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:14361558-14475737
Strand Forward strand
Band A1
Transcripts
ENSMUST00000100167 ENSMUSP00000097743
ENSMUST00000133454 ENSMUSP00000122656
ENSMUST00000147759 ENSMUSP00000115627
ENSMUST00000130671 ENSMUSP00000116714
ENSMUST00000154748 ENSMUSP00000115763
ENSMUST00000134776 ENSMUSP00000120933
ENSMUST00000144676 ENSMUSP00000116726
ENSMUST00000144074
ENSMUST00000156089
ENSMUST00000134960
ENSMUST00000146032
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005324 long-chain fatty acid transporter activity
GO:0005524 ATP binding
GO:0008559 xenobiotic-transporting ATPase activity
GO:0015431 glutathione S-conjugate-exporting ATPase activity
GO:0015562 efflux transmembrane transporter activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0034040 lipid-transporting ATPase activity
GO:0034634 glutathione transmembrane transporter activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0046624 sphingolipid transporter activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0006979 response to oxidative stress
GO:0015911 plasma membrane long-chain fatty acid transport
GO:0030335 positive regulation of cell migration
GO:0033700 phospholipid efflux
GO:0046618 drug export
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral to plasma membrane
GO:0016021 integral to membrane
GO:0016323 basolateral plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Arachidonic acid metabolism pathway
KEGG
ABC transporters pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
ABC-family proteins mediated transport pathway
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Arachidonic acid metabolism pathway
KEGG
ABC transporters pathway
INOH
PID BIOCARTA
Multi-drug resistance factors [Biocarta view]
PID NCI
Sphingosine 1-phosphate (S1P) pathway
S1P1 pathway
Cross-References
SwissProt O35379
TrEMBL A5D6P3 D3YYJ6 D3YZY1 D3Z407 E9Q1I5 Q3UDM1 Q8BRD0 Q8C7V6
UniProt Splice Variant
Entrez Gene 17250
UniGene Mm.196634 Mm.408568 Mm.441319
RefSeq NM_008576
OMIM
CCDS CCDS37264
HPRD
IMGT
MGI ID 102676 MGI:102676
MGI Symbol Abcc1
EMBL AC154265 AF022908 AK029876 AK045109 AK049174 AK150015 BC090617 CH466521
GenPept AAB80938 AAH90617 BAC26654 BAC32226 BAC33586 BAE29240 EDK97393
ImmGen Abcc1 (murine)
RNA Seq Atlas 17250