Version 5.4
Homo sapiens Gene: ADM2
Summary
InnateDB Gene IDBG-13523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADM2
Gene Name adrenomedullin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128165
Encoded Proteins
IDBP-238952
adrenomedullin 2
IDBP-238954
adrenomedullin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which is a member of the calcitonin-related hormones. The encoded protein is involved in maintaining homeostasis in many tissues, acting via CRLR/RAMP receptor (calcitonin receptor-like receptor/receptor activity-modifying protein) complexes. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:50481556-50486440
Strand Forward strand
Band q13.33
Transcripts
ENST00000395738 ENSP00000379087
ENST00000395737 ENSP00000379086
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0032403 protein complex binding
Biological Process
GO:0001525 angiogenesis
GO:0006468 protein phosphorylation
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007586 digestion
GO:0007631 feeding behavior
GO:0010628 positive regulation of gene expression
GO:0045766 positive regulation of angiogenesis
GO:0045776 negative regulation of blood pressure
Cellular Component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18290
Calcitonin-like ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q7Z4H4
TrEMBL
UniProt Splice Variant
Entrez Gene 79924
UniGene Hs.449099 Hs.735385 Hs.743540
RefSeq NM_001253845 NM_024866
HUGO HGNC:28898
OMIM 608682
CCDS CCDS33682
HPRD
IMGT
EMBL AB121034 AB236970 AF529213 AL096767
GenPept AAQ09100 BAD07411 BAE46395 CAO03464
RNA Seq Atlas 79924

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca