Mus musculus Gene: Ccr6 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-135484.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Ccr6 | ||||||||||||||||||||||
Gene Name | chemokine (C-C motif) receptor 6 | ||||||||||||||||||||||
Synonyms | CC-CKR-6; CCR-6; Cmkbr6; KY411 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000040899 | ||||||||||||||||||||||
Encoded Proteins |
chemokine (C-C motif) receptor 6
chemokine (C-C motif) receptor 6
chemokine (C-C motif) receptor 6
chemokine (C-C motif) receptor 6
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
Ccr6 mobilizes TCR-alpha/beta+, Ccr6+ innate and adaptive effector T cells in the airway in response to mycobacterial infection. Ccr6 is not required for induction of the adaptive antimycobacterial response
Ccr6 is a chemokine receptor that only binds to a single chemokine ligand, Ccl20. Ccr6 is an important receptor that is involved in regulating mucosal immunity by mediating the recruitment of dendritic cells and APCs to the sites of epithelial inflammation.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Homo sapiens] CCR6 mobilizes TCR-alpha/beta+, CCR6+ innate and adaptive effector T cells in the airway in response to mycobacterial infection. CCR6 is not required for induction of the adaptive antimycobacterial response
[Homo sapiens] CCR6 is a chemokine receptor that only binds to a single chemokine ligand, CCL20. CCR6 is an important receptor that is involved in regulating mucosal immunity by mediating the recruitment of dendritic cells and APCs to the sites of epithelial inflammation.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112486:
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 17:8236043-8257127 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | A1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Defensins pathway
Beta defensins pathway
Innate Immune System pathway
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Immune System pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
G alpha (i) signalling events pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
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KEGG |
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Beta defensins pathway
Defensins pathway
G alpha (i) signalling events pathway
Chemokine receptors bind chemokines pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Innate Immune System pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
GPCR ligand binding pathway
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KEGG |
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | O54689 | ||||||||||||||||||||||
TrEMBL | Q3U467 Q542B6 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 12458 | ||||||||||||||||||||||
UniGene | Mm.418621 Mm.8007 | ||||||||||||||||||||||
RefSeq | NM_009835 XM_006523285 XM_006523287 XM_006523290 NM_001190333 NM_001190334 NM_001190335 NM_001190336 NM_001190337 NM_001190338 XM_006523289 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS28381 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1333797 | ||||||||||||||||||||||
MGI Symbol | Ccr6 | ||||||||||||||||||||||
EMBL | AB009369 AJ222714 AK089712 AK154413 BC100756 BC100757 BC100758 BC105669 CH466619 | ||||||||||||||||||||||
GenPept | AAI00757 AAI00758 AAI00759 AAI05670 BAA23776 BAC40946 BAE32567 CAA10956 EDL02125 | ||||||||||||||||||||||
RNA Seq Atlas | 12458 | ||||||||||||||||||||||