InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sema3a

Summary

InnateDB Gene

IDBG-135492.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sema3a

Gene Name

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

Synonyms

coll-1; Hsema-I; SEMA1; Semad; SemD

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028883

Encoded Proteins

IDBP-135494

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

IDBP-135496

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

IDBP-541968

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

IDBP-623317

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

IDBP-539187

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21098092

Sema3a is a ligand for Plxna4, and the overexpression of Sema3a exacerbate cytokine storm caused by Tlr agonist and bacterial sepsis. The expression of Sema3a can be induced by Tlr engagement, and thus completes an autocrine loop.

InnateDB Annotation from Orthologs

Summary

PMID 21098092

[Homo sapiens] SEMA3A is a ligand for PLXNA4, and the overexpression of SEMA3A exacerbate cytokine storm caused by TLR agonist and bacterial sepsis. The expression of SEMA3A can be induced by TLR engagement, and thus completes an autocrine loop.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075213:
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer\'s disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:13396784-13602565

Strand

Forward strand

Band

Transcripts

ENSMUST00000095012	ENSMUSP00000092621
ENSMUST00000030714	ENSMUSP00000030714
ENSMUST00000125629	ENSMUSP00000121710
ENSMUST00000137798	ENSMUSP00000128153
ENSMUST00000141968	ENSMUSP00000122621

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030215	semaphorin receptor binding
GO:0038191	neuropilin binding
GO:0045499	chemorepellent activity

Biological Process

GO:0001764	neuron migration
GO:0002027	regulation of heart rate
GO:0006915	apoptotic process
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0008045	motor neuron axon guidance
GO:0010633	negative regulation of epithelial cell migration
GO:0021612	facial nerve structural organization
GO:0021637	trigeminal nerve structural organization
GO:0021675	nerve development
GO:0021772	olfactory bulb development
GO:0021785	branchiomotor neuron axon guidance
GO:0021828	gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0030517	negative regulation of axon extension
GO:0045087	innate immune response (InnateDB)
GO:0048813	dendrite morphogenesis
GO:0048841	regulation of axon extension involved in axon guidance
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0048846	axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0060385	axonogenesis involved in innervation
GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching
GO:0061549	sympathetic ganglion development
GO:0071526	semaphorin-plexin signaling pathway
GO:0097490	sympathetic neuron projection extension
GO:0097491	sympathetic neuron projection guidance
GO:1901166	neural crest cell migration involved in autonomic nervous system development
GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance
GO:1903045	neural crest cell migration involved in sympathetic nervous system development
GO:2000020	positive regulation of male gonad development
GO:2001224	positive regulation of neuron migration