InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Syn1

Summary

InnateDB Gene

IDBG-135538.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syn1

Gene Name

synapsin I

Synonyms

Syn-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037217

Encoded Proteins

IDBP-135540

synapsin I

IDBP-249837

synapsin I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008056:
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:20860511-20921004

Strand

Reverse strand

Band

A1.3

Transcripts

ENSMUST00000081893	ENSMUSP00000080568
ENSMUST00000115345	ENSMUSP00000111002

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0007269	neurotransmitter secretion
GO:0008152	metabolic process

Cellular Component

GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043229	intracellular organelle

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000008056

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_15293

Dopamine Neurotransmitter Release Cycle pathway

REACT_15425

Serotonin Neurotransmitter Release Cycle pathway

REACT_13685

Neuronal System pathway

REACT_13477

Transmission across Chemical Synapses pathway

REACT_13723

Neurotransmitter Release Cycle pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

O88935

TrEMBL

W8QPF2

UniProt Splice Variant

Entrez Gene

20964

UniGene

Mm.439844

RefSeq

NM_001110780 NM_013680

OMIM

CCDS

CCDS53017 CCDS53018

HPRD

IMGT

MGI ID

MGI:98460

MGI Symbol

Syn1

EMBL

AF085809 BC022954 KJ174470 L32025

GenPept

AAA79963 AAD09833 AAH22954 AHL39032

RNA Seq Atlas

20964