Version 5.4
Mus musculus Gene: Cfp
Summary
InnateDB Gene IDBG-135734.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cfp
Gene Name complement factor properdin
Synonyms BCFG; Pfc
Species Mus musculus
Ensembl Gene ENSMUSG00000001128
Encoded Proteins
IDBP-135736
complement factor properdin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25725105
Cfp plays a role in intestinal homeostasis in response to an infectious challenge to activate Hc (C5a), which in turn provides protection through Il6 expression by the epithelium.
InnateDB Annotation from Orthologs
Summary
PMID 18579773
[Homo sapiens] CFP binds to early apoptotic T cells and initiates complement activation, leading to C3B opsonization and ingestion by phagocytic cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126759:
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:20925454-20931555
Strand Reverse strand
Band A1.3
Transcripts
ENSMUST00000001156 ENSMUSP00000001156
ENSMUST00000122862
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006957 complement activation, alternative pathway
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000126759
View Gene Order
ENSBTAG00000015815
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_211817
O-glycosylation of TSR domain-containing proteins pathway
REACT_208792
Complement cascade pathway
REACT_198562
Regulation of Complement cascade pathway
REACT_230745
Immune System pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_218037
Alternative complement activation pathway
REACT_202834
Initial triggering of complement pathway
REACT_213087
Activation of C3 and C5 pathway
REACT_204003
O-linked glycosylation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_7972
Activation of C3 and C5 pathway
REACT_8001
Alternative complement activation pathway
REACT_8024
Initial triggering of complement pathway
REACT_118707
Regulation of Complement cascade pathway
REACT_22161
Post-translational protein modification pathway
REACT_6802
Innate Immune System pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
REACT_200626
O-glycosylation of TSR domain-containing proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3064 Mm.408590
RefSeq NM_008823
OMIM
CCDS CCDS30047
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca