Version 5.4
Mus musculus Gene: Ubr5
Summary
InnateDB Gene IDBG-135895.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ubr5
Gene Name ubiquitin protein ligase E3 component n-recognin 5
Synonyms Edd; Edd1
Species Mus musculus
Ensembl Gene ENSMUSG00000037487
Encoded Proteins
IDBP-260475
ubiquitin protein ligase E3 component n-recognin 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104517:
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:37967328-38078853
Strand Reverse strand
Band B3.1
Transcripts
ENSMUST00000110336 ENSMUSP00000105965
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 69 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0034450 ubiquitin-ubiquitin ligase activity
GO:0043130 ubiquitin binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0033160 positive regulation of protein import into nucleus, translocation
GO:0035413 positive regulation of catenin import into nucleus
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0050847 progesterone receptor signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901315 negative regulation of histone H2A K63-linked ubiquitination
GO:2000780 negative regulation of double-strand break repair
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104517
View Gene Order
ENSBTAG00000021209
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9Q2H1 Q8BJK5
UniProt Splice Variant
Entrez Gene 70790
UniGene Mm.476840
RefSeq NM_001081359 NM_001112721 XM_006520179 XM_006520180 XM_006520181 XM_006520182 XM_006520183
OMIM
CCDS CCDS49595
HPRD
IMGT
MGI ID MGI:1918040
MGI Symbol Ubr5
EMBL AC122035 AC122291 AK083545
GenPept BAC38949
RNA Seq Atlas 70790

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca