InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Agtr2

Summary

InnateDB Gene

IDBG-136032.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agtr2

Gene Name

angiotensin II receptor, type 2

Synonyms

AI316812; AW107640

Species

Mus musculus

Ensembl Gene

ENSMUSG00000068122

Encoded Proteins

IDBP-136034

angiotensin II receptor, type 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180772:
The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:21484544-21489164

Strand

Forward strand

Band

Transcripts

ENSMUST00000089188	ENSMUSP00000086592
ENSMUST00000131150

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004945	angiotensin type II receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0017046	peptide hormone binding

Biological Process

GO:0001822	kidney development
GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0002018	renin-angiotensin regulation of aldosterone production
GO:0002033	vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
GO:0002035	brain renin-angiotensin system
GO:0006883	cellular sodium ion homeostasis
GO:0006954	inflammatory response
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0008284	positive regulation of cell proliferation
GO:0010243	response to organonitrogen compound
GO:0010459	negative regulation of heart rate
GO:0010700	negative regulation of norepinephrine secretion
GO:0021695	cerebellar cortex development
GO:0032304	negative regulation of icosanoid secretion
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0035556	intracellular signal transduction
GO:0035566	regulation of metanephros size
GO:0035640	exploration behavior
GO:0035815	positive regulation of renal sodium excretion
GO:0035932	aldosterone secretion
GO:0038166	angiotensin-activated signaling pathway
GO:0042416	dopamine biosynthetic process
GO:0042990	regulation of transcription factor import into nucleus
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045909	positive regulation of vasodilation
GO:0048147	negative regulation of fibroblast proliferation
GO:0050715	positive regulation of cytokine secretion
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway
GO:0060993	kidney morphogenesis
GO:0061049	cell growth involved in cardiac muscle cell development
GO:0071549	cellular response to dexamethasone stimulus
GO:0072300	positive regulation of metanephric glomerulus development
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway