Version 5.4
Mus musculus Gene: Cacna2d1
Summary
InnateDB Gene IDBG-136210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacna2d1
Gene Name calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms Ca(v)alpha2delta1; Cacna2; Cchl2a
Species Mus musculus
Ensembl Gene ENSMUSG00000040118
Encoded Proteins
IDBP-136212
calcium channel, voltage-dependent, alpha2/delta subunit 1
IDBP-136214
calcium channel, voltage-dependent, alpha2/delta subunit 1
IDBP-136442
calcium channel, voltage-dependent, alpha2/delta subunit 1
IDBP-249936
calcium channel, voltage-dependent, alpha2/delta subunit 1
IDBP-623525
calcium channel, voltage-dependent, alpha2/delta subunit 1
IDBP-724892
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a regulatory component of the voltage-dependent calcium channel complex. The product of this gene is a proprotein that is proteolytically processed into alpha-2 and delta subunits, which are linked by a disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:15934691-16374511
Strand Forward strand
Band A2
Transcripts
ENSMUST00000078272 ENSMUSP00000077391
ENSMUST00000039370 ENSMUSP00000049457
ENSMUST00000101581 ENSMUSP00000099117
ENSMUST00000115281 ENSMUSP00000110936
ENSMUST00000167946 ENSMUSP00000131507
ENSMUST00000180204 ENSMUSP00000136260
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006816 calcium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0051924 regulation of calcium ion transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005891 voltage-gated calcium channel complex
GO:0016529 sarcoplasmic reticulum
GO:0030315 T-tubule
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000153956
View Gene Order
ENSBTAG00000020569
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04010
MAPK signaling pathway pathway
mmu04260
Cardiac muscle contraction pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.159842 Mm.475525
RefSeq NM_001110843 NM_001110844 NM_001110845 NM_001110846 NM_009784 XM_006535616 XM_006535617 XM_006535619
OMIM
CCDS CCDS19096 CCDS51421 CCDS51422 CCDS51423
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca