Homo sapiens Gene: TLR1 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-13627.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | TLR1 | ||||||||||||||||||||||||||||
Gene Name | toll-like receptor 1 | ||||||||||||||||||||||||||||
Synonyms | CD281; rsc786; TIL; TIL. LPRS5 | ||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000174125 | ||||||||||||||||||||||||||||
Encoded Proteins |
toll-like receptor 1
toll-like receptor 1
toll-like receptor 1
toll-like receptor 1
toll-like receptor 1
toll-like receptor 1
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||
Summary |
TLR1 polymorphisms affect innate immune responses and outcomes in sepsis.
TLR1 restrains potentially dangerous innate response to LPS by binding to TLR4 and preventing the formation of active signalling complexes.
TLR1 interacts with TLR2 to recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.
TLR1 and TLR6 are involved in the discrimination of a subtle difference between triacyl and diacyl lipopeptides through interaction with TLR2.
TLR1 :: TLR2 dimeric pairs recognize malarial glycosylphosphatidylinositols (GPI) to initiates intracellular signalling and the production of pro-inflammatory cytokines.
TLR1 is a critical innate receptor for protective intestinal T(H)17 immunity against Yersinia enterocolitica. (Demonstrated in mice)
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||
Summary |
[Mus musculus] Tlr1 :: Tlr2 dimeric pairs recognize malarial glycosylphosphatidylinositols (GPI) to initiates intracellular signalling and the production of pro-inflammatory cytokines.
[Mus musculus] Tlr1 is a critical innate receptor for protective intestinal T(H)17 immunity against Yersinia enterocolitica.
[Mus musculus] TLR1 in intestinal epithelium mediates activation and recruitment of dendritic cells to mount mucosal immunity against Yersinia enterocolitica.
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Entrez Gene | |||||||||||||||||||||||||||||
Summary |
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 4:38790677-38856817 | ||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||
Band | p14 | ||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||||||||
KEGG |
Toll-like receptor signaling pathway pathway
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INOH | |||||||||||||||||||||||||||||
PID NCI |
Endogenous TLR signaling
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Cross-References | |||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
UniGene | Hs.621817 Hs.654532 | ||||||||||||||||||||||||||||
RefSeq | NM_003263 XM_005262662 XM_005262663 XM_005262665 XM_005262666 XM_006714028 | ||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | CCDS33973 | ||||||||||||||||||||||||||||
HPRD | 03119 | ||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||