InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pkp2

Summary

InnateDB Gene

IDBG-136561.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pkp2

Gene Name

plakophilin 2

Synonyms

1200008D14Rik; 1200012P04Rik; AA516617; Pkp2l

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041957

Encoded Proteins

IDBP-136563

plakophilin 2

IDBP-537754

plakophilin 2

IDBP-540223

plakophilin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000057294:
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:16213318-16272712

Strand

Forward strand

Band

Transcripts

ENSMUST00000039408	ENSMUSP00000036890
ENSMUST00000162150	ENSMUSP00000124898
ENSMUST00000161342	ENSMUSP00000125219

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005488	binding
GO:0005515	protein binding
GO:0019215	intermediate filament binding
GO:0032947	protein complex scaffold

Biological Process

GO:0002159	desmosome assembly
GO:0007507	heart development
GO:0016337	single organismal cell-cell adhesion
GO:0045110	intermediate filament bundle assembly
GO:0048496	maintenance of organ identity
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086019	cell-cell signaling involved in cardiac conduction
GO:0086069	bundle of His cell to Purkinje myocyte communication
GO:0086091	regulation of heart rate by cardiac conduction

Cellular Component

GO:0005634	nucleus
GO:0005882	intermediate filament
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0014704	intercalated disc
GO:0030054	cell junction
GO:0030057	desmosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000057294

View Gene Order

ENSBTAG00000002651

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05412

Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

hsa05412

Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.2252

RefSeq

NM_026163

OMIM

CCDS

CCDS27981

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas