Version 5.4
Mus musculus Gene: Il15ra
Summary
InnateDB Gene IDBG-136731.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il15ra
Gene Name interleukin 15 receptor, alpha chain
Synonyms AA690181; IL-15RA
Species Mus musculus
Ensembl Gene ENSMUSG00000023206
Encoded Proteins
IDBP-136737
interleukin 15 receptor, alpha chain
IDBP-250933
interleukin 15 receptor, alpha chain
IDBP-250935
interleukin 15 receptor, alpha chain
IDBP-250937
interleukin 15 receptor, alpha chain
IDBP-250939
interleukin 15 receptor, alpha chain
IDBP-624523
interleukin 15 receptor, alpha chain
IDBP-624530
interleukin 15 receptor, alpha chain
IDBP-624533
interleukin 15 receptor, alpha chain
IDBP-624535
interleukin 15 receptor, alpha chain
IDBP-624538
interleukin 15 receptor, alpha chain
IDBP-624540
interleukin 15 receptor, alpha chain
IDBP-541918
interleukin 15 receptor, alpha chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134470:
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:11705287-11733986
Strand Forward strand
Band A1
Transcripts
ENSMUST00000091456
ENSMUST00000078834 ENSMUSP00000077878
ENSMUST00000114834 ENSMUSP00000110483
ENSMUST00000114833 ENSMUSP00000110482
ENSMUST00000114832 ENSMUSP00000110481
ENSMUST00000114831 ENSMUSP00000110480
ENSMUST00000135341 ENSMUSP00000132731
ENSMUST00000138349 ENSMUSP00000131473
ENSMUST00000123600 ENSMUSP00000130792
ENSMUST00000128156 ENSMUSP00000126364
ENSMUST00000130245
ENSMUST00000148748 ENSMUSP00000132058
ENSMUST00000126394 ENSMUSP00000131640
ENSMUST00000138856 ENSMUSP00000120539
ENSMUST00000124448
ENSMUST00000133975
ENSMUST00000139774
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007259 JAK-STAT cascade
GO:0010977 negative regulation of neuron projection development
GO:0031667 response to nutrient levels
GO:0032825 positive regulation of natural killer cell differentiation
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000134470
View Gene Order
ENSBTAG00000006078
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04672
Intestinal immune network for IgA production pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.200196
RefSeq NM_001271498 NM_001271499 NM_001271500 NM_001271501 NM_008358 NM_133836
OMIM
CCDS CCDS15686 CCDS15687 CCDS70977 CCDS70978 CCDS70979 CCDS70980
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca