InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc22a3

Summary

InnateDB Gene

IDBG-136760.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc22a3

Gene Name

solute carrier family 22 (organic cation transporter), member 3

Synonyms

EMT; Oct3; Orct3; Slca22a3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023828

Encoded Proteins

IDBP-136762

solute carrier family 22 (organic cation transporter), member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25561729

[Homo sapiens] SLC22A3 deficiency significantly decreases lipopolysaccharide- induced monocytic inflammatory response by interrupting NF-kB and MAPKs (mitogen-activated protein kinases) signalling cascades in a histamine dependent manner.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146477:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:12419972-12507704

Strand

Reverse strand

Band

Transcripts

ENSMUST00000024595

ENSMUSP00000024595

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005329	dopamine transmembrane transporter activity
GO:0005515	protein binding
GO:0015075	ion transmembrane transporter activity
GO:0015101	organic cation transmembrane transporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0019534	toxin transporter activity
GO:0022857	transmembrane transporter activity

Biological Process

GO:0015695	organic cation transport
GO:0015697	quaternary ammonium group transport
GO:0015844	monoamine transport
GO:0015872	dopamine transport
GO:0032098	regulation of appetite
GO:0034220	ion transmembrane transport
GO:0051608	histamine transport
GO:0051615	histamine uptake
GO:0055085	transmembrane transport
GO:1901998	toxin transport