InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc22a1

Summary

InnateDB Gene

IDBG-136910.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc22a1

Gene Name

solute carrier family 22 (organic cation transporter), member 1

Synonyms

Lx1; Oct1; Orct; Orct1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000023829

Encoded Proteins

IDBP-136912

solute carrier family 22 (organic cation transporter), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175003:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:12648874-12675838

Strand

Reverse strand

Band

Transcripts

ENSMUST00000024596

ENSMUSP00000024596

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005277	acetylcholine transmembrane transporter activity
GO:0005329	dopamine transmembrane transporter activity
GO:0005333	norepinephrine transmembrane transporter activity
GO:0005515	protein binding
GO:0008504	monoamine transmembrane transporter activity
GO:0008513	secondary active organic cation transmembrane transporter activity
GO:0015075	ion transmembrane transporter activity
GO:0015101	organic cation transmembrane transporter activity
GO:0015651	quaternary ammonium group transmembrane transporter activity
GO:0022857	transmembrane transporter activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006812	cation transport
GO:0006836	neurotransmitter transport
GO:0006855	drug transmembrane transport
GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
GO:0015695	organic cation transport
GO:0015697	quaternary ammonium group transport
GO:0015844	monoamine transport
GO:0015872	dopamine transport
GO:0015874	norepinephrine transport
GO:0034220	ion transmembrane transport
GO:0048241	epinephrine transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:1901374	acetate ester transport