Version 5.4
Mus musculus Gene: Ap3m1
Summary
InnateDB Gene IDBG-137016.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ap3m1
Gene Name adaptor-related protein complex 3, mu 1 subunit
Synonyms 1200013D09Rik; C78982; R75378
Species Mus musculus
Ensembl Gene ENSMUSG00000021824
Encoded Proteins
IDBP-137018
adaptor-related protein complex 3, mu 1 subunit
IDBP-538435
adaptor-related protein complex 3, mu 1 subunit
IDBP-540266
adaptor-related protein complex 3, mu 1 subunit
IDBP-539844
adaptor-related protein complex 3, mu 1 subunit
IDBP-535559
adaptor-related protein complex 3, mu 1 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185009:
The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane and may be directly involved in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:21031442-21052508
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000022371 ENSMUSP00000022371
ENSMUST00000154460 ENSMUSP00000117346
ENSMUST00000131469
ENSMUST00000122974
ENSMUST00000126536 ENSMUSP00000116046
ENSMUST00000156716
ENSMUST00000148886
ENSMUST00000130291 ENSMUSP00000118259
ENSMUST00000130370 ENSMUSP00000115157
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0008089 anterograde axon cargo transport
GO:0016192 vesicle-mediated transport
GO:0048490 anterograde synaptic vesicle transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0030131 clathrin adaptor complex
GO:0030659 cytoplasmic vesicle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185009
View Gene Order
ENSBTAG00000021883
Not yet available
Pathways
NETPATH
REACTOME
REACT_258900
Chaperonin-mediated protein folding pathway
REACT_244970
Association of TriC/CCT with target proteins during biosynthesis pathway
REACT_247926
Metabolism of proteins pathway
REACT_245534
Protein folding pathway
KEGG
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16907
Association of TriC/CCT with target proteins during biosynthesis pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.376269 Mm.398879 Mm.402204 Mm.439005
RefSeq NM_018829 XM_006519292 XM_006519293
OMIM
CCDS CCDS26861
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca