InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fgd4

Summary

InnateDB Gene

IDBG-137062.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgd4

Gene Name

FYVE, RhoGEF and PH domain containing 4

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022788

Encoded Proteins

IDBP-137064

FYVE, RhoGEF and PH domain containing 4

IDBP-533345

FYVE, RhoGEF and PH domain containing 4

IDBP-534998

FYVE, RhoGEF and PH domain containing 4

IDBP-532251

FYVE, RhoGEF and PH domain containing 4

IDBP-535184

FYVE, RhoGEF and PH domain containing 4

IDBP-539200

FYVE, RhoGEF and PH domain containing 4

IDBP-535742

FYVE, RhoGEF and PH domain containing 4

IDBP-625268

FYVE, RhoGEF and PH domain containing 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139132:
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:16416917-16600549

Strand

Reverse strand

Band

Transcripts

ENSMUST00000069284	ENSMUSP00000069573
ENSMUST00000161861	ENSMUSP00000125174
ENSMUST00000162671	ENSMUSP00000125736
ENSMUST00000161188	ENSMUSP00000123763
ENSMUST00000162045	ENSMUSP00000125435
ENSMUST00000162124	ENSMUSP00000125165
ENSMUST00000159542	ENSMUSP00000125649
ENSMUST00000159058
ENSMUST00000162414
ENSMUST00000162542
ENSMUST00000161624
ENSMUST00000172181	ENSMUSP00000131870

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0046872	metal ion binding

Biological Process

GO:0007257	activation of JUN kinase activity
GO:0030032	lamellipodium assembly
GO:0030035	microspike assembly
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction