InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adk

Summary

InnateDB Gene

IDBG-137102.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adk

Gene Name

adenosine kinase

Synonyms

2310026J05Rik; 5033405D03Rik; AI255373; AI987814; Ak

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039197

Encoded Proteins

IDBP-137104

adenosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156110:
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:21052574-21448568

Strand

Forward strand

Band

Transcripts

ENSMUST00000045376

ENSMUSP00000047665

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004001	adenosine kinase activity
GO:0005524	ATP binding
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006166	purine ribonucleoside salvage
GO:0006175	dATP biosynthetic process
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0016310	phosphorylation
GO:0032922	circadian regulation of gene expression
GO:0042102	positive regulation of T cell proliferation
GO:0044209	AMP salvage
GO:0044342	type B pancreatic cell proliferation
GO:0046085	adenosine metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000156110

View Gene Order

ENSBTAG00000011072

Not yet available

Pathways

NETPATH

REACTOME

REACT_263730

Purine metabolism pathway

REACT_188937

Metabolism pathway

REACT_244050

Purine salvage pathway

REACT_245662

Metabolism of nucleotides pathway

KEGG

mmu00230

Purine metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_1923

Purine salvage pathway

REACT_1698

Metabolism of nucleotides pathway

REACT_522

Purine metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00230

Purine metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

P55264

TrEMBL

Q3TZR1 Q8BWS6

UniProt Splice Variant

Entrez Gene

11534

UniGene

RefSeq

NM_001243041 NM_134079 XM_006518441

OMIM

CCDS

CCDS26862

HPRD

IMGT

MGI ID

MGI:87930

MGI Symbol

Adk

EMBL

AK050135 AK157662 AY540996 AY540997 BC009659 U26589

GenPept

AAA91649 AAH09659 AAT07065 AAT07066 BAC34087 BAE34146

RNA Seq Atlas

11534