InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mcph1

Summary

InnateDB Gene

IDBG-137280.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mcph1

Gene Name

microcephaly, primary autosomal recessive 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039842

Encoded Proteins

IDBP-137282

microcephaly, primary autosomal recessive 1

IDBP-626438

microcephaly, primary autosomal recessive 1

IDBP-626440

microcephaly, primary autosomal recessive 1

IDBP-540846

microcephaly, primary autosomal recessive 1

IDBP-531621

microcephaly, primary autosomal recessive 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147316:
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:18595131-18803189

Strand

Forward strand

Band

A1.3

Transcripts

ENSMUST00000039412	ENSMUSP00000037000
ENSMUST00000124910	ENSMUSP00000131698
ENSMUST00000153133
ENSMUST00000146819	ENSMUSP00000131616
ENSMUST00000133417	ENSMUSP00000121636
ENSMUST00000141244	ENSMUSP00000119267

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0010468	regulation of gene expression
GO:0021987	cerebral cortex development
GO:0043549	regulation of kinase activity
GO:0046605	regulation of centrosome cycle
GO:0050727	regulation of inflammatory response
GO:0060348	bone development
GO:0060623	regulation of chromosome condensation
GO:0071539	protein localization to centrosome
GO:0097150	neuronal stem cell maintenance