Version 5.4
Mus musculus Gene: Fermt3
Summary
InnateDB Gene IDBG-137957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fermt3
Gene Name fermitin family homolog 3 (Drosophila)
Synonyms C79673; Kindlin3
Species Mus musculus
Ensembl Gene ENSMUSG00000024965
Encoded Proteins
IDBP-137961
fermitin family homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149781:
Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:6998958-7019469
Strand Reverse strand
Band A
Transcripts
ENSMUST00000040772 ENSMUSP00000037858
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005515 protein binding
Biological Process
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0033622 integrin activation
GO:0033632 regulation of cell-cell adhesion mediated by integrin
GO:0034446 substrate adhesion-dependent cell spreading
GO:0070527 platelet aggregation
Cellular Component
GO:0002102 podosome
GO:0016020 membrane
GO:0030054 cell junction
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000149781
View Gene Order
Cross-References
SwissProt Q8K1B8
TrEMBL Q3TEE6
UniProt Splice Variant
Entrez Gene 108101
UniGene Mm.157591
RefSeq NM_153795 XM_006526593
OMIM
CCDS CCDS29518
HPRD
IMGT
MGI ID MGI:2147790
MGI Symbol Fermt3
EMBL AK169682 BC025119 BC032204
GenPept AAH25119 AAH32204 BAE41302
RNA Seq Atlas 108101

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca