Version 5.4
Homo sapiens Gene: GPX4
Summary
InnateDB Gene IDBG-13826.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPX4
Gene Name glutathione peroxidase 4
Synonyms GPx-4; GSHPx-4; MCSP; PHGPx; snGPx; snPHGPx
Species Homo sapiens
Ensembl Gene ENSG00000167468
Encoded Proteins
IDBP-13828
glutathione peroxidase 4 (phospholipid hydroperoxidase)
IDBP-761873
IDBP-766221
IDBP-762410
IDBP-765805
IDBP-809753
glutathione peroxidase 4
IDBP-765103
IDBP-809749
glutathione peroxidase 4
IDBP-809754
glutathione peroxidase 4
IDBP-809758
glutathione peroxidase 4
IDBP-809760
glutathione peroxidase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. [provided by RefSeq, Jul 2008]
This gene encodes a member of the glutathione peroxidase protein family. Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. The encoded protein has been identified as a moonlighting protein based on its ability to serve dual functions as a peroxidase as well as a structural protein in mature spermatozoa. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:1103926-1106791
Strand Forward strand
Band p13.3
Transcripts
ENST00000354171 ENSP00000346103
ENST00000593032 ENSP00000465828
ENST00000585480 ENSP00000467900
ENST00000587648 ENSP00000468349
ENST00000587932
ENST00000589115 ENSP00000466872
ENST00000585362 ENSP00000473614
ENST00000592940
ENST00000588919 ENSP00000464989
ENST00000611653 ENSP00000483655
ENST00000614791 ENSP00000484697
ENST00000622390 ENSP00000477503
ENST00000616066 ENSP00000485000
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004602 glutathione peroxidase activity
GO:0008430 selenium binding
GO:0043295 glutathione binding
GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity
Biological Process
GO:0006325 chromatin organization
GO:0006644 phospholipid metabolic process
GO:0006749 glutathione metabolic process
GO:0006979 response to oxidative stress
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007568 aging
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0032355 response to estradiol
GO:0042744 hydrogen peroxide catabolic process
GO:0044281 small molecule metabolic process
GO:0050727 regulation of inflammatory response
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000075706
View Gene Order
Pathways
NETPATH
REACTOME
REACT_150422
Synthesis of 15-eicosatetraenoic acid derivatives pathway
REACT_150209
Synthesis of 5-eicosatetraenoic acids pathway
REACT_150201
Synthesis of 12-eicosatetraenoic acid derivatives pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00480
Glutathione metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.601590
RefSeq NM_001039847 NM_001039848 NM_002085
HUGO
OMIM
CCDS CCDS42457
HPRD 11819
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca