InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc25a5

Summary

InnateDB Gene

IDBG-138331.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc25a5

Gene Name

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5

Synonyms

Ant2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000016319

Encoded Proteins

IDBP-138333

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005022:
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Sep 2009]
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:36795651-36798807

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000016463	ENSMUSP00000016463
ENSMUST00000126608
ENSMUST00000156672

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	86 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007059	chromosome segregation
GO:0008284	positive regulation of cell proliferation
GO:0055085	transmembrane transport
GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042645	mitochondrial nucleoid
GO:0070062	extracellular vesicular exosome
GO:0071817	MMXD complex