Version 5.4
Mus musculus Gene: Thbs2
Summary
InnateDB Gene IDBG-138710.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Thbs2
Gene Name thrombospondin 2
Synonyms Thbs-2; TSP2
Species Mus musculus
Ensembl Gene ENSMUSG00000023885
Encoded Proteins
IDBP-620775
thrombospondin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186340:
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:14665500-14694262
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000170872 ENSMUSP00000128308
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008201 heparin binding
Biological Process
GO:0007155 cell adhesion
GO:0016525 negative regulation of angiogenesis
GO:0051965 positive regulation of synapse assembly
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000186340
View Gene Order
ENSBTAG00000018810
Not yet available
Pathways
NETPATH
REACTOME
REACT_263353
Signaling by PDGF pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04512
ECM-receptor interaction pathway
mmu04510
Focal adhesion pathway
mmu05144
Malaria pathway
mmu04145
Phagosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16888
Signaling by PDGF pathway
REACT_22161
Post-translational protein modification pathway
REACT_111102
Signal Transduction pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
REACT_200626
O-glycosylation of TSR domain-containing proteins pathway
KEGG
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05144
Malaria pathway
hsa04145
Phagosome pathway
INOH
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
Cross-References
SwissProt Q03350
TrEMBL Q8K2B7
UniProt Splice Variant
Entrez Gene 21826
UniGene Mm.26688
RefSeq NM_011581
OMIM
CCDS CCDS49958
HPRD
IMGT
MGI ID MGI:98738
MGI Symbol Thbs2
EMBL AF549256 BC031843 CH466630 L07803 M64866
GenPept AAA40432 AAA53064 AAH31843 AAO16244 EDL20481
RNA Seq Atlas 21826

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca