InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: U2af2

Summary

InnateDB Gene

IDBG-139851.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

U2af2

Gene Name

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2

Synonyms

65kDa

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030435

Encoded Proteins

IDBP-139853

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2

IDBP-621195

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000063244:
U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:5062143-5079945

Strand

Forward strand

Band

Transcripts

ENSMUST00000005041	ENSMUSP00000005041
ENSMUST00000165399	ENSMUSP00000131458

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 123 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	123 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding
GO:0070742	C2H2 zinc finger domain binding