InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lamp2

Summary

InnateDB Gene

IDBG-140038.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lamp2

Gene Name

lysosomal-associated membrane protein 2

Synonyms

CD107b; Lamp II; Lamp-2; Lamp-2a; Lamp-2b; Lamp-2c; LGP-B; Mac3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000016534

Encoded Proteins

IDBP-140040

lysosomal-associated membrane protein 2

IDBP-140042

lysosomal-associated membrane protein 2

IDBP-140044

lysosomal-associated membrane protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005893:
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:38401357-38456454

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000074913	ENSMUSP00000074448
ENSMUST00000016678	ENSMUSP00000016678
ENSMUST00000061755	ENSMUSP00000052283
ENSMUST00000136817
ENSMUST00000144663

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding

Biological Process

GO:0050821

protein stabilization

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030670	phagocytic vesicle membrane
GO:0031088	platelet dense granule membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000005893

View Gene Order

ENSBTAG00000007399

Not yet available

Pathways

NETPATH

REACTOME

REACT_230203

Platelet degranulation pathway

REACT_224553

Hemostasis pathway

REACT_224879

Platelet activation, signaling and aggregation pathway

REACT_206166

Response to elevated platelet cytosolic Ca2+ pathway

KEGG

mmu04142

Lysosome pathway

mmu04145

Phagosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_318

Platelet degranulation pathway

REACT_1280

Response to elevated platelet cytosolic Ca2+ pathway

REACT_798

Platelet activation, signaling and aggregation pathway

REACT_604

Hemostasis pathway

KEGG

hsa04142

Lysosome pathway

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

P17047

TrEMBL

Q8C5K0

UniProt Splice Variant

Entrez Gene

16784

UniGene

Mm.393333 Mm.395238 Mm.399636 Mm.400366 Mm.414016 Mm.418582

RefSeq

NM_001017959 NM_001290485 NM_010685 XM_006541430

OMIM

CCDS

CCDS30092 CCDS30093 CCDS72369

HPRD

IMGT

MGI ID

MGI:96748

MGI Symbol

Lamp2

EMBL

AK032974 AK078193 AK159272 AK163933 AL513356 BC138718 BC138723 CH466570 J05287 M32017 M32018

GenPept

AAA39412 AAA39429 AAA39430 AAI38719 AAI38724 BAC28106 BAC37169 BAE34951 BAE37543 CAM17143 CAM17144 EDL29015 EDL29016 EDL29018

RNA Seq Atlas

16784