Homo sapiens Gene: CHRNA2
Summary
InnateDB Gene IDBG-14049.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHRNA2
Gene Name cholinergic receptor, nicotinic, alpha 2 (neuronal)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120903
Encoded Proteins
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
Protein Structure
Entrez Gene
Summary Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:27459762-27479883
Strand Reverse strand
Band p21.2
Transcripts
ENST00000240132 ENSP00000240132
ENST00000407991 ENSP00000385026
ENST00000520600
ENST00000523529
ENST00000523695 ENSP00000430612
ENST00000520933 ENSP00000429616
ENST00000522008
ENST00000524096 ENSP00000430422
ENST00000518712 ENSP00000430856
ENST00000520650
ENST00000521921 ENSP00000429953
ENST00000520208 ENSP00000430994
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004889 acetylcholine-activated cation-selective channel activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0008144 drug binding
GO:0015464 acetylcholine receptor activity
GO:0042166 acetylcholine binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0051291 protein heterooligomerization
Cellular Component
GO:0005886 plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Neuronal System pathway
Highly calcium permeable nicotinic acetylcholine receptors pathway
Postsynaptic nicotinic acetylcholine receptors pathway
Activation of Nicotinic Acetylcholine Receptors pathway
Presynaptic nicotinic acetylcholine receptors pathway
Transmission across Chemical Synapses pathway
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Acetylcholine Binding And Downstream Events pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q15822
TrEMBL E5RGP6 E5RGT4 E5RHQ4 E5RJ54 E5RK67
UniProt Splice Variant
Entrez Gene 1135
UniGene Hs.57718
RefSeq NM_000742 NM_001282455 XM_005273397 XM_006716282 XM_006716283
HUGO HGNC:1956
OMIM 118502
CCDS CCDS6059 CCDS64856
HPRD 00332
IMGT
EMBL AF311103 AK296348 BC153866 U62431 Y16281
GenPept AAB40109 AAI53867 BAG59031 CAA76154
ImmGen CHRNA2 (murine)
RNA Seq Atlas 1135