Homo sapiens Gene: CHRNA2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-14049.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CHRNA2 | ||||||||||||||||||
Gene Name | cholinergic receptor, nicotinic, alpha 2 (neuronal) | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000120903 | ||||||||||||||||||
Encoded Proteins |
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
cholinergic receptor, nicotinic, alpha 2 (neuronal)
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 8:27459762-27479883 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | p21.2 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Neuronal System pathway
Highly calcium permeable nicotinic acetylcholine receptors pathway
Postsynaptic nicotinic acetylcholine receptors pathway
Activation of Nicotinic Acetylcholine Receptors pathway
Presynaptic nicotinic acetylcholine receptors pathway
Transmission across Chemical Synapses pathway
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Acetylcholine Binding And Downstream Events pathway
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KEGG |
Neuroactive ligand-receptor interaction pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.57718 | ||||||||||||||||||
RefSeq | NM_000742 NM_001282455 XM_005273397 XM_006716282 XM_006716283 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS6059 CCDS64856 | ||||||||||||||||||
HPRD | 00332 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||