Homo sapiens Gene: CHRNA2

Summary
InnateDB Gene IDBG-14049.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol CHRNA2
Gene Name cholinergic receptor, nicotinic, alpha 2 (neuronal)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120903
Encoded Proteins
IDBP-14051 cholinergic receptor, nicotinic, alpha 2 (neuronal)
IDBP-294779 cholinergic receptor, nicotinic, alpha 2 (neuronal)
IDBP-480929 cholinergic receptor, nicotinic, alpha 2 (neuronal)
IDBP-475682 cholinergic receptor, nicotinic, alpha 2 (neuronal)
IDBP-485398 cholinergic receptor, nicotinic, alpha 2 (neuronal)
IDBP-482159 cholinergic receptor, nicotinic, alpha 2 (neuronal)
IDBP-482748 cholinergic receptor, nicotinic, alpha 2 (neuronal)
IDBP-479201 cholinergic receptor, nicotinic, alpha 2 (neuronal)
Entrez Gene
Summary Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8: 27317279-27337400
Strand Reverse strand
Band p21.2
Transcripts
ENST00000240132  ENSP00000240132
ENST00000407991  ENSP00000385026
ENST00000520600 
ENST00000523529 
ENST00000523695  ENSP00000430612
ENST00000520933  ENSP00000429616
ENST00000522008 
ENST00000524096  ENSP00000430422
ENST00000518712  ENSP00000430856
ENST00000520650 
ENST00000521921  ENSP00000429953
ENST00000520208  ENSP00000430994
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein‑Protein  0
Protein‑DNA 1
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0004889 acetylcholine-activated cation-selective channel activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0015464 acetylcholine receptor activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
Cellular Component
GO:0005886 plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0016020 membrane
GO:0016021 integral to membrane
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
GO:0071944 cell periphery
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000022041 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000002252 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa04080  Neuroactive ligand-receptor interaction
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q15822 
TrEMBL E5RGP6 E5RGT4 E5RHQ4 E5RJ54 E5RK67 J3KMY9
UniProt Splice Variant
Entrez Gene 1135 
UniGene Hs.57718
RefSeq NM_000742 
HUGO 1956 
OMIM 118502
CCDS CCDS6059 
HPRD 00332
IMGT
EMBL AF311103 BC153866 U62431 Y16281
GenPept AAB40109  AAI53867  CAA76154 
ImmGen CHRNA2 (murine) 
RNA Seq Atlas 1135