Version 5.4
Homo sapiens Gene: TAPBPL
Summary
InnateDB Gene IDBG-14065.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAPBPL
Gene Name TAP binding protein-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139192
Encoded Proteins
IDBP-14067
TAP binding protein-like
IDBP-592392
TAP binding protein-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:6451690-6466517
Strand Forward strand
Band p13.31
Transcripts
ENST00000266556 ENSP00000266556
ENST00000539384
ENST00000544826
ENST00000544021 ENSP00000445341
ENST00000545700
ENST00000543567
ENST00000542160
ENST00000544289
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0032403 protein complex binding
Biological Process
GO:0002590 negative regulation of antigen processing and presentation of peptide antigen via MHC class I
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038213
View Gene Order
ENSBTAG00000014728
Not yet available
Cross-References
SwissProt
TrEMBL G3V1T3
UniProt Splice Variant
Entrez Gene 55080
UniGene Hs.504597 Hs.682600
RefSeq NM_018009
HUGO HGNC:30683
OMIM 607081
CCDS CCDS8546
HPRD 06153
IMGT
EMBL AC005840 CH471116
GenPept EAW88799
RNA Seq Atlas 55080

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca