InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lama2

Summary

InnateDB Gene

IDBG-140720.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lama2

Gene Name

laminin, alpha 2

Synonyms

5830440B04; dy; mer; merosin; mKIAA4087

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019899

Encoded Proteins

IDBP-140722

laminin, alpha 2

IDBP-789047

laminin, alpha 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196569:
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:26980036-27619758

Strand

Reverse strand

Band

Transcripts

ENSMUST00000092639	ENSMUSP00000090304
ENSMUST00000186279
ENSMUST00000189575	ENSMUSP00000140716
ENSMUST00000185839
ENSMUST00000186965
ENSMUST00000188963
ENSMUST00000187535

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0016192	vesicle-mediated transport
GO:0022011	myelination in peripheral nervous system
GO:0030155	regulation of cell adhesion
GO:0030198	extracellular matrix organization
GO:0030334	regulation of cell migration
GO:0032224	positive regulation of synaptic transmission, cholinergic
GO:0045995	regulation of embryonic development

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005606	laminin-1 complex
GO:0016020	membrane
GO:0042383	sarcolemma
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome