Version 5.4
Homo sapiens Gene: SLIRP
Summary
InnateDB Gene IDBG-14081.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLIRP
Gene Name SRA stem-loop interacting RNA binding protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000119705
Encoded Proteins
IDBP-14083
SRA stem-loop interacting RNA binding protein
IDBP-588251
SRA stem-loop interacting RNA binding protein
IDBP-597846
SRA stem-loop interacting RNA binding protein
IDBP-592348
SRA stem-loop interacting RNA binding protein
IDBP-601108
SRA stem-loop interacting RNA binding protein
IDBP-595110
SRA stem-loop interacting RNA binding protein
IDBP-598324
SRA stem-loop interacting RNA binding protein
IDBP-589076
SRA stem-loop interacting RNA binding protein
IDBP-593516
SRA stem-loop interacting RNA binding protein
IDBP-808576
SRA stem-loop interacting RNA binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:77708071-77761104
Strand Forward strand
Band q24.3
Transcripts
ENST00000238688 ENSP00000238688
ENST00000557342 ENSP00000450909
ENST00000557623 ENSP00000452057
ENST00000557431 ENSP00000450849
ENST00000555890 ENSP00000451606
ENST00000556831 ENSP00000450770
ENST00000554074
ENST00000556375 ENSP00000452162
ENST00000556310 ENSP00000452329
ENST00000553981 ENSP00000450587
ENST00000556956
ENST00000613856 ENSP00000478794
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 33 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000961 negative regulation of mitochondrial RNA catabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007286 spermatid development
GO:0007338 single fertilization
GO:0030317 sperm motility
GO:0070584 mitochondrion morphogenesis
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0030529 ribonucleoprotein complex
GO:0036126 sperm flagellum
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021040
View Gene Order
ENSBTAG00000008135
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001267863 NM_001267864 NM_031210
HUGO
OMIM
CCDS CCDS58331 CCDS73668 CCDS9866
HPRD 12639
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca