Mus musculus Gene: Hdac3 | |||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-140814.6 | ||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||
Gene Symbol | Hdac3 | ||||||||||||||||||||||||||||||||
Gene Name | histone deacetylase 3 | ||||||||||||||||||||||||||||||||
Synonyms | AW537363 | ||||||||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000024454 | ||||||||||||||||||||||||||||||||
Encoded Proteins |
histone deacetylase 3
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Protein Structure | |||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171720:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 18:37935844-37954988 | ||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||
Band | B3 | ||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 254 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||
Species
Homo sapiens
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||
REACTOME |
Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes pathway
Transcriptional regulation of white adipocyte differentiation pathway
Mus musculus biological processes pathway
Chromatin organization pathway
Disease pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Circadian Clock pathway
REV-ERBA represses gene expression pathway
RORA activates circadian gene expression pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Chromatin modifying enzymes pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signalling by NGF pathway
PPARA activates gene expression pathway
Developmental Biology pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
HDACs deacetylate histones pathway
Signaling by NOTCH pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
p75NTR negatively regulates cell cycle via SC1 pathway
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KEGG | |||||||||||||||||||||||||||||||||
INOH |
TGF-beta signaling pathway
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PID NCI | |||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||
REACTOME |
p75NTR negatively regulates cell cycle via SC1 pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
PPARA activates gene expression pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
RORA activates circadian gene expression pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REV-ERBA represses gene expression pathway
Circadian Clock pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Transcriptional regulation of white adipocyte differentiation pathway
Organelle biogenesis and maintenance pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Metabolism of lipids and lipoproteins pathway
Signaling by NOTCH1 in Cancer pathway
Mitochondrial biogenesis pathway
p75 NTR receptor-mediated signalling pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
HDACs deacetylate histones pathway
Transcriptional activation of mitochondrial biogenesis pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Chromatin organization pathway
Signaling by NOTCH pathway
Chromatin modifying enzymes pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Metabolism pathway
Disease pathway
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KEGG | |||||||||||||||||||||||||||||||||
INOH |
TGF-beta signaling pathway
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PID NCI |
Regulation of retinoblastoma protein
Validated targets of C-MYC transcriptional repression
Signaling events mediated by HDAC Class I
Signaling events mediated by HDAC Class II
Retinoic acid receptors-mediated signaling
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Cross-References | |||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||
UniGene | Mm.20521 | ||||||||||||||||||||||||||||||||
RefSeq | NM_010411 | ||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||
CCDS | CCDS37785 | ||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||