Version 5.4
Mus musculus Gene: Spry1
Summary
InnateDB Gene IDBG-140824.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spry1
Gene Name sprouty homolog 1 (Drosophila)
Synonyms sprouty1
Species Mus musculus
Ensembl Gene ENSMUSG00000037211
Encoded Proteins
IDBP-140826
sprouty homolog 1 (Drosophila)
IDBP-265227
sprouty homolog 1 (Drosophila)
IDBP-265229
sprouty homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164056:
Gene Information
Type Protein coding
Genomic Location Chromosome 3:37639947-37644598
Strand Forward strand
Band B
Transcripts
ENSMUST00000038569 ENSMUSP00000049292
ENSMUST00000108109 ENSMUSP00000103744
ENSMUST00000108107 ENSMUSP00000103742
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000132 establishment of mitotic spindle orientation
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001759 organ induction
GO:0007275 multicellular organismal development
GO:0008285 negative regulation of cell proliferation
GO:0009966 regulation of signal transduction
GO:0034261 negative regulation of Ras GTPase activity
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0043407 negative regulation of MAP kinase activity
GO:0046580 negative regulation of Ras protein signal transduction
GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway
GO:0060449 bud elongation involved in lung branching
GO:0070373 negative regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164056
View Gene Order
ENSBTAG00000021245
Not yet available
Pathways
NETPATH
REACTOME
REACT_203917
EGFR downregulation pathway
REACT_189085
Disease pathway
REACT_242976
Signaling by EGFR pathway
REACT_188257
Signal Transduction pathway
REACT_188180
Signaling by EGFR in Cancer pathway
KEGG
mmu04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_116125
Disease pathway
KEGG
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.330986 Mm.474123
RefSeq NM_011896 XM_006535465 XM_006535466
OMIM
CCDS CCDS17322
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca