InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Polb

Summary

InnateDB Gene

IDBG-140909.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Polb

Gene Name

polymerase (DNA directed), beta

Synonyms

A430088C08Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031536

Encoded Proteins

IDBP-140911

polymerase (DNA directed), beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070501:
The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:22628119-22653437

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033938

ENSMUSP00000033938

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003824	catalytic activity
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0016779	nucleotidyltransferase activity
GO:0016829	lyase activity
GO:0019899	enzyme binding
GO:0046872	metal ion binding

Biological Process

GO:0006261	DNA-dependent DNA replication
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006287	base-excision repair, gap-filling
GO:0006290	pyrimidine dimer repair
GO:0006974	cellular response to DNA damage stimulus
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0045471	response to ethanol
GO:0051402	neuron apoptotic process
GO:0071897	DNA biosynthetic process