InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tesk1

Summary

InnateDB Gene

IDBG-140945.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tesk1

Gene Name

testis specific protein kinase 1

Synonyms

AI326901

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028458

Encoded Proteins

IDBP-140947

testis specific protein kinase 1

IDBP-540348

testis specific protein kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107140:
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:43441939-43448064

Strand

Forward strand

Band

Transcripts

ENSMUST00000060864	ENSMUSP00000050087
ENSMUST00000138981	ENSMUSP00000121067
ENSMUST00000126350
ENSMUST00000137178
ENSMUST00000156810

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007283	spermatogenesis
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000107140

View Gene Order

ENSBTAG00000011406

Not yet available

Pathways

NETPATH

REACTOME

REACT_243772

Cell-extracellular matrix interactions pathway

REACT_241978

Cell junction organization pathway

REACT_223082

Cell-Cell communication pathway

REACT_255191

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_20580

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components pathway

REACT_20649

Cell-extracellular matrix interactions pathway

REACT_111155

Cell-Cell communication pathway

REACT_20676

Cell junction organization pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.10154 Mm.485441

RefSeq

NM_011571

OMIM

CCDS

CCDS18094

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas