Version 5.4
Mus musculus Gene: Taf6l
Summary
InnateDB Gene IDBG-140953.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Taf6l
Gene Name TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
Synonyms 0610031L02Rik; 1500003K22Rik; 1810059G22Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000003680
Encoded Proteins
IDBP-140957
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
IDBP-704907
IDBP-704957
IDBP-705340
IDBP-704625
IDBP-789854
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162227:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:8772522-8786417
Strand Reverse strand
Band A
Transcripts
ENSMUST00000003777 ENSMUSP00000003777
ENSMUST00000176719
ENSMUST00000177056 ENSMUSP00000135028
ENSMUST00000176747
ENSMUST00000176610 ENSMUSP00000135193
ENSMUST00000177216 ENSMUSP00000135220
ENSMUST00000176688
ENSMUST00000176080
ENSMUST00000176496 ENSMUSP00000135090
ENSMUST00000176991
ENSMUST00000176331
ENSMUST00000189739 ENSMUSP00000140136
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006352 DNA-templated transcription, initiation
GO:0008150 biological_process
GO:0043966 histone H3 acetylation
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0016021 integral component of membrane
GO:0030914 STAGA complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000162227
View Gene Order
ENSBTAG00000009484
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_226917
HATs acetylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
KEGG
mmu03022
Basal transcription factors pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_172610
HATs acetylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
hsa03022
Basal transcription factors pathway
INOH
PID NCI
Cross-References
SwissProt Q8R2K4
TrEMBL
UniProt Splice Variant
Entrez Gene 67706
UniGene Mm.220886 Mm.490619
RefSeq NM_001177798 NM_026325 NM_146092
OMIM
CCDS CCDS29545 CCDS29546 CCDS57134
HPRD
IMGT
MGI ID MGI:2444957
MGI Symbol Taf6l
EMBL AK077149 BC028647
GenPept AAH28647 BAC36645
RNA Seq Atlas 225895 67706

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca