Version 5.4
Homo sapiens Gene: LIPC
Summary
InnateDB Gene IDBG-14108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIPC
Gene Name lipase, hepatic
Synonyms HDLCQ12; HL; HTGL; LIPH
Species Homo sapiens
Ensembl Gene ENSG00000166035
Encoded Proteins
IDBP-14110
lipase, hepatic
IDBP-36028
lipase, hepatic
IDBP-373875
lipase, hepatic
IDBP-373876
lipase, hepatic
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:58410569-58569843
Strand Forward strand
Band q21.3
Transcripts
ENST00000299022 ENSP00000299022
ENST00000356113 ENSP00000348425
ENST00000433326 ENSP00000395002
ENST00000414170 ENSP00000395569
ENST00000560257
ENST00000559845
ENST00000560664
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004620 phospholipase activity
GO:0004806 triglyceride lipase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0016298 lipase activity
GO:0030169 low-density lipoprotein particle binding
GO:0034185 apolipoprotein binding
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0019433 triglyceride catabolic process
GO:0030301 cholesterol transport
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0034373 intermediate-density lipoprotein particle remodeling
GO:0034374 low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034382 chylomicron remnant clearance
GO:0034638 phosphatidylcholine catabolic process
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0034364 high-density lipoprotein particle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032207
View Gene Order
ENSBTAG00000005479
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654472
RefSeq NM_000236 XM_005254372 XM_005254374 XM_006720501 XM_006720502
HUGO
OMIM
CCDS CCDS10166
HPRD 01058
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca