Homo sapiens Gene: LIPC

Summary
InnateDB Gene IDBG-14108.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol LIPC
Gene Name lipase, hepatic
Synonyms HDLCQ12; HL; HTGL; LIPH
Species Homo sapiens
Ensembl Gene ENSG00000166035
Encoded Proteins
IDBP-14110 lipase, hepatic
IDBP-36028 lipase, hepatic
IDBP-373875 lipase, hepatic
IDBP-373876 lipase, hepatic
Entrez Gene
Summary LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15: 58702768-58861151
Strand Forward strand
Band q21.3
Transcripts
ENST00000299022  ENSP00000299022
ENST00000356113  ENSP00000348425
ENST00000433326  ENSP00000395002
ENST00000414170  ENSP00000395569
ENST00000560257 
ENST00000559845 
ENST00000560664 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein‑Protein  4
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 24 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0004620 phospholipase activity
GO:0004806 triglyceride lipase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0016298 lipase activity
GO:0030169 low-density lipoprotein particle binding
GO:0034185 apolipoprotein binding
GO:0050253 retinyl-palmitate esterase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0019433 triglyceride catabolic process
GO:0030301 cholesterol transport
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0034373 intermediate-density lipoprotein particle remodeling
GO:0034374 low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034382 chylomicron remnant clearance
GO:0034638 phosphatidylcholine catabolic process
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0034364 high-density lipoprotein particle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000032207 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000005479 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
REACT_6841 Chylomicron-mediated lipid transport
KEGG
hsa00561  Glycerolipid metabolism
hsa01100  Metabolic pathways
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P11150 
TrEMBL E7EUJ1 E7EUK6
UniProt Splice Variant
Entrez Gene 3990 
UniGene Hs.654472
RefSeq NM_000236 
HUGO 6619 
OMIM 151670
CCDS CCDS10166 
HPRD 01058
IMGT
EMBL AC018904 AC084781 AF037404 AK292631 AK315306 BC132825 BC136495 D83062 D83548 J03540 J03895 M29186 M29187 M29188 M29189 M29190 M29191 M29192 M29193 M29194 M35425 M35426 M35427 M35429 M35430 M35431 M35432 M35433 X07228
GenPept AAA59520  AAA59521  AAA61165  AAB60702  AAC34206  AAI32826  AAI36496  BAA11760  BAA12014  BAF85320  BAG37710  CAA30188 
ImmGen LIPC (murine) 
RNA Seq Atlas 3990