InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cdk5

Summary

InnateDB Gene

IDBG-141112.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdk5

Gene Name

cyclin-dependent kinase 5

Synonyms

AW048668; Crk6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028969

Encoded Proteins

IDBP-141114

cyclin-dependent kinase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164885:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:24418250-24423530

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030814

ENSMUSP00000030814

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005176	ErbB-2 class receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008092	cytoskeletal protein binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0030549	acetylcholine receptor activator activity
GO:0043125	ErbB-3 class receptor binding
GO:0046875	ephrin receptor binding
GO:0050321	tau-protein kinase activity

Biological Process

GO:0001764	neuron migration
GO:0001963	synaptic transmission, dopaminergic
GO:0006468	protein phosphorylation
GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0006913	nucleocytoplasmic transport
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0007160	cell-matrix adhesion
GO:0007409	axonogenesis
GO:0007416	synapse assembly
GO:0007519	skeletal muscle tissue development
GO:0008045	motor neuron axon guidance
GO:0008306	associative learning
GO:0008542	visual learning
GO:0009611	response to wounding
GO:0009790	embryo development
GO:0014044	Schwann cell development
GO:0016310	phosphorylation
GO:0016477	cell migration
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0019233	sensory perception of pain
GO:0021537	telencephalon development
GO:0021549	cerebellum development
GO:0021695	cerebellar cortex development
GO:0021697	cerebellar cortex formation
GO:0021766	hippocampus development
GO:0021819	layer formation in cerebral cortex
GO:0021954	central nervous system neuron development
GO:0021987	cerebral cortex development
GO:0022038	corpus callosum development
GO:0030182	neuron differentiation
GO:0030334	regulation of cell migration
GO:0030517	negative regulation of axon extension
GO:0030866	cortical actin cytoskeleton organization
GO:0030900	forebrain development
GO:0031175	neuron projection development
GO:0031397	negative regulation of protein ubiquitination
GO:0031914	negative regulation of synaptic plasticity
GO:0032092	positive regulation of protein binding
GO:0032801	receptor catabolic process
GO:0033136	serine phosphorylation of STAT3 protein
GO:0035249	synaptic transmission, glutamatergic
GO:0035418	protein localization to synapse
GO:0042220	response to cocaine
GO:0043113	receptor clustering
GO:0043525	positive regulation of neuron apoptotic process
GO:0045055	regulated secretory pathway
GO:0045786	negative regulation of cell cycle
GO:0045860	positive regulation of protein kinase activity
GO:0045861	negative regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045956	positive regulation of calcium ion-dependent exocytosis
GO:0046777	protein autophosphorylation
GO:0046826	negative regulation of protein export from nucleus
GO:0048148	behavioral response to cocaine
GO:0048167	regulation of synaptic plasticity
GO:0048488	synaptic vesicle endocytosis
GO:0048511	rhythmic process
GO:0048709	oligodendrocyte differentiation
GO:0048812	neuron projection morphogenesis
GO:0048813	dendrite morphogenesis
GO:0051301	cell division
GO:0051402	neuron apoptotic process
GO:0060078	regulation of postsynaptic membrane potential
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0061001	regulation of dendritic spine morphogenesis
GO:0070509	calcium ion import
GO:0090314	positive regulation of protein targeting to membrane
GO:1901215	negative regulation of neuron death
GO:2000273	positive regulation of receptor activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030175	filopodium
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0031594	neuromuscular junction
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0045211	postsynaptic membrane