Version 5.4
Mus musculus Gene: Rtn4r
Summary
InnateDB Gene IDBG-141120.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rtn4r
Gene Name reticulon 4 receptor
Synonyms NgR; NgR1; NOGOR
Species Mus musculus
Ensembl Gene ENSMUSG00000043811
Encoded Proteins
IDBP-141122
reticulon 4 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000040608:
This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:18127642-18152408
Strand Forward strand
Band A3
Transcripts
ENSMUST00000059589 ENSMUSP00000062924
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007409 axonogenesis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031225 anchored component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000040608
View Gene Order
Pathways
NETPATH
REACTOME
REACT_222662
p75NTR regulates axonogenesis pathway
REACT_203657
Axonal growth inhibition (RHOA activation) pathway
REACT_248921
Signalling by NGF pathway
REACT_188257
Signal Transduction pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13815
Axonal growth inhibition (RHOA activation) pathway
REACT_11061
Signalling by NGF pathway
REACT_13620
p75NTR regulates axonogenesis pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
p75ntrpathway
p75(NTR)-mediated signaling
Cross-References
SwissProt Q99PI8
TrEMBL
UniProt Splice Variant
Entrez Gene 65079
UniGene Mm.40149
RefSeq NM_022982
OMIM
CCDS CCDS37279
HPRD
IMGT
MGI ID MGI:2136886
MGI Symbol Rtn4r
EMBL AF283462 BC052317 BC058381
GenPept AAG53611 AAH52317 AAH58381
RNA Seq Atlas 65079

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca