Version 5.4
Mus musculus Gene: Dgcr8
Summary
InnateDB Gene IDBG-141484.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dgcr8
Gene Name DiGeorge syndrome critical region gene 8
Synonyms D16H22S1742E; D16H22S788E; D16Wis2; Gy1; N41; Vo59c07
Species Mus musculus
Ensembl Gene ENSMUSG00000022718
Encoded Proteins
IDBP-141486
DiGeorge syndrome critical region gene 8
IDBP-249208
DiGeorge syndrome critical region gene 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128191:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:18253948-18289249
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000009321 ENSMUSP00000009321
ENSMUST00000115633 ENSMUSP00000111296
ENSMUST00000152033
ENSMUST00000144536
ENSMUST00000128856
ENSMUST00000156274
ENSMUST00000134431
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0031053 primary miRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000128191
View Gene Order
ENSBTAG00000019869
Not yet available
Pathways
NETPATH
REACTOME
REACT_221178
MicroRNA (miRNA) biogenesis pathway
REACT_233572
Gene Expression pathway
REACT_206535
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12417
MicroRNA (miRNA) biogenesis pathway
REACT_71
Gene Expression pathway
REACT_12472
Regulatory RNA pathways pathway
REACT_210102
MicroRNA (miRNA) biogenesis pathway
REACT_226022
Gene Expression pathway
REACT_210892
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_033324 XM_006522796 XM_006536877 XM_006544952
OMIM
CCDS CCDS28018
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca