InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADAM10

Summary

InnateDB Gene

IDBG-14155.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAM10

Gene Name

ADAM metallopeptidase domain 10

Synonyms

AD10; AD18; CD156c; HsT18717; kuz; MADM; RAK

Species

Homo sapiens

Ensembl Gene

ENSG00000137845

Encoded Proteins

IDBP-14157

ADAM metallopeptidase domain 10

IDBP-747469

IDBP-294040

ADAM metallopeptidase domain 10

IDBP-373921

ADAM metallopeptidase domain 10

IDBP-806500

ADAM metallopeptidase domain 10

IDBP-589753

ADAM metallopeptidase domain 10

IDBP-603791

ADAM metallopeptidase domain 10

IDBP-591541

ADAM metallopeptidase domain 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18981120

ADAM10 associates with tetraspanins and regulates cleavage of TNF (TNF-alpha) and EGF (epidermal growth factor).

Entrez Gene

Summary

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:58588807-58749978

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000260408	ENSP00000260408
ENST00000396136	ENSP00000456542
ENST00000402627	ENSP00000386056
ENST00000439637	ENSP00000391930
ENST00000482945
ENST00000470269
ENST00000462061
ENST00000481164
ENST00000475898
ENST00000497846
ENST00000461408	ENSP00000481779
ENST00000561288	ENSP00000452639
ENST00000559053	ENSP00000453952
ENST00000558733
ENST00000558004	ENSP00000452704
ENST00000560608
ENST00000561149

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004222	metalloendopeptidase activity
GO:0005102	receptor binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001701	in utero embryonic development
GO:0006468	protein phosphorylation
GO:0006508	proteolysis
GO:0006509	membrane protein ectodomain proteolysis
GO:0007162	negative regulation of cell adhesion
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007229	integrin-mediated signaling pathway
GO:0007267	cell-cell signaling
GO:0008219	cell death
GO:0008284	positive regulation of cell proliferation
GO:0010820	positive regulation of T cell chemotaxis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0030574	collagen catabolic process
GO:0034612	response to tumor necrosis factor
GO:0042117	monocyte activation
GO:0045087	innate immune response (InnateDB)
GO:0051088	PMA-inducible membrane protein ectodomain proteolysis
GO:0051089	constitutive protein ectodomain proteolysis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005798	Golgi-associated vesicle
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome
GO:0097038	perinuclear endoplasmic reticulum
GO:0097197	tetraspanin-enriched microdomain