Version 5.4
Mus musculus Gene: Arhgap26
Summary
InnateDB Gene IDBG-141860.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgap26
Gene Name Rho GTPase activating protein 26
Synonyms 1810044B20Rik; 2610010G17Rik; 4933432P15Rik; AI853435; mKIAA0621
Species Mus musculus
Ensembl Gene ENSMUSG00000036452
Encoded Proteins
IDBP-141862
Rho GTPase activating protein 26
IDBP-538510
Rho GTPase activating protein 26
IDBP-537362
Rho GTPase activating protein 26
IDBP-542782
Rho GTPase activating protein 26
IDBP-541835
Rho GTPase activating protein 26
IDBP-538969
Rho GTPase activating protein 26
IDBP-541096
Rho GTPase activating protein 26
IDBP-788802
Rho GTPase activating protein 26
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145819:
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:38601534-39376284
Strand Forward strand
Band B3
Transcripts
ENSMUST00000097593 ENSMUSP00000095200
ENSMUST00000115580
ENSMUST00000115574
ENSMUST00000145090
ENSMUST00000127448
ENSMUST00000149112
ENSMUST00000134388
ENSMUST00000148850 ENSMUSP00000121894
ENSMUST00000156167
ENSMUST00000155576 ENSMUSP00000122371
ENSMUST00000123820
ENSMUST00000154551 ENSMUSP00000123145
ENSMUST00000137497 ENSMUSP00000121197
ENSMUST00000148399
ENSMUST00000141058 ENSMUSP00000119865
ENSMUST00000151757 ENSMUSP00000122448
ENSMUST00000133247
ENSMUST00000187912 ENSMUSP00000141188
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008093 cytoskeletal adaptor activity
GO:0017124 SH3 domain binding
Biological Process
GO:0007165 signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0046847 filopodium assembly
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145819
View Gene Order
ENSBTAG00000027151
Not yet available
Pathways
NETPATH
REACTOME
REACT_206918
Signaling by Rho GTPases pathway
REACT_210090
Rho GTPase cycle pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11051
Rho GTPase cycle pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
fak_pathway
Signaling events mediated by focal adhesion kinase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.244585 Mm.329396 Mm.398146 Mm.443985
RefSeq NM_001033789 NM_175164 XM_006526264 XM_006526265 XM_006526266 XM_006526269
OMIM
CCDS CCDS29205
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca