InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mta2

Summary

InnateDB Gene

IDBG-142016.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mta2

Gene Name

metastasis-associated gene family, member 2

Synonyms

AW550797; Mata1l1; mmta2; Mta1l1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000071646

Encoded Proteins

IDBP-142018

metastasis-associated gene family, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149480:
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:8941875-8952303

Strand

Forward strand

Band

Transcripts

ENSMUST00000096240	ENSMUSP00000093959
ENSMUST00000137956
ENSMUST00000135300
ENSMUST00000132463
ENSMUST00000151386
ENSMUST00000169535

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	47 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	66 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000989	transcription factor binding transcription factor activity
GO:0001085	RNA polymerase II transcription factor binding
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0031492	nucleosomal DNA binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0006323	DNA packaging
GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0016575	histone deacetylation
GO:0043044	ATP-dependent chromatin remodeling
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0016020	membrane
GO:0016581	NuRD complex
GO:0043234	protein complex