InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nr3c1

Summary

InnateDB Gene

IDBG-142259.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nr3c1

Gene Name

nuclear receptor subfamily 3, group C, member 1

Synonyms

GR; Grl-1; Grl1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024431

Encoded Proteins

IDBP-142261

nuclear receptor subfamily 3, group C, member 1

IDBP-142263

nuclear receptor subfamily 3, group C, member 1

IDBP-249331

nuclear receptor subfamily 3, group C, member 1

IDBP-249335

nuclear receptor subfamily 3, group C, member 1

IDBP-542036

nuclear receptor subfamily 3, group C, member 1

IDBP-541799

nuclear receptor subfamily 3, group C, member 1

IDBP-541790

nuclear receptor subfamily 3, group C, member 1

IDBP-534464

nuclear receptor subfamily 3, group C, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21750107

The Glucocorticoid receptor, Nr3c1 exerts anti-inflammatory action in part by antagonizing pro-inflammatory transcription factors such as Rela of the NFkB complex. (Demonstrated in human)

PMID 21940629

Nr3c1, the glucocorticoid receptor, is necessary for glucocorticoid-mediated induction of Nlrp3 and the subsequent formation of inflammasomes, demonstrating a novel role for glucocorticoids in sensitizing the initial inflammatory response by the innate immune system.

InnateDB Annotation from Orthologs

Summary

PMID 21750107

[Homo sapiens] The Glucocorticoid receptor, NR3C1, exerts anti-inflammatory action in part by antagonizing pro-inflammatory transcription factors such as RELA of the NFkB complex.

PMID 21940629

[Homo sapiens] NR3C1, the glucocorticoid receptor, is necessary for glucocorticoid-mediated induction of NLRP3 and the subsequent formation of inflammasomes, demonstrating a novel role for glucocorticoids in sensitizing the initial inflammatory response by the innate immune system. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113580:
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:39410545-39491301

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025300	ENSMUSP00000025300
ENSMUST00000097592	ENSMUSP00000095199
ENSMUST00000115571	ENSMUSP00000111233
ENSMUST00000115567	ENSMUSP00000111229
ENSMUST00000152853	ENSMUSP00000120082
ENSMUST00000124115	ENSMUSP00000119630
ENSMUST00000131885	ENSMUSP00000121144
ENSMUST00000150483	ENSMUSP00000119432

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 180 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	180 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004883	glucocorticoid receptor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006111	regulation of gluconeogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008211	glucocorticoid metabolic process
GO:0030325	adrenal gland development
GO:0031946	regulation of glucocorticoid biosynthetic process
GO:0042921	glucocorticoid receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0043402	glucocorticoid mediated signaling pathway
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060603	mammary gland duct morphogenesis
GO:1900170	negative regulation of glucocorticoid mediated signaling pathway