Version 5.4
Mus musculus Gene: Cacna1b
Summary
InnateDB Gene IDBG-142643.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cacna1b
Gene Name calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms alpha(1B); AW050276; AW060892; AW822256; Cav2.2; Cchn1a
Species Mus musculus
Ensembl Gene ENSMUSG00000004113
Encoded Proteins
IDBP-142645
calcium channel, voltage-dependent, N type, alpha 1B subunit
IDBP-142647
calcium channel, voltage-dependent, N type, alpha 1B subunit
IDBP-142649
calcium channel, voltage-dependent, N type, alpha 1B subunit
IDBP-142651
calcium channel, voltage-dependent, N type, alpha 1B subunit
IDBP-251712
calcium channel, voltage-dependent, N type, alpha 1B subunit
IDBP-541761
calcium channel, voltage-dependent, N type, alpha 1B subunit
IDBP-532090
calcium channel, voltage-dependent, N type, alpha 1B subunit
IDBP-541082
calcium channel, voltage-dependent, N type, alpha 1B subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000148408:
The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:24603887-24763152
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000102939 ENSMUSP00000100003
ENSMUST00000100348 ENSMUSP00000097920
ENSMUST00000070864 ENSMUSP00000063236
ENSMUST00000041342 ENSMUSP00000037416
ENSMUST00000114447 ENSMUSP00000110090
ENSMUST00000131861
ENSMUST00000133892 ENSMUSP00000115285
ENSMUST00000125798
ENSMUST00000155356 ENSMUSP00000116674
ENSMUST00000124183 ENSMUSP00000114605
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008331 high voltage-gated calcium channel activity
Biological Process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007269 neurotransmitter secretion
GO:0007626 locomotory behavior
GO:0008016 regulation of heart contraction
GO:0008217 regulation of blood pressure
GO:0034765 regulation of ion transmembrane transport
GO:0048265 response to pain
GO:0051924 regulation of calcium ion transport
GO:0055085 transmembrane transport
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0086010 membrane depolarization during action potential
Cellular Component
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000148408
View Gene Order
ENSBTAG00000007882
Not yet available
Pathways
NETPATH
REACTOME
REACT_225645
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_259290
Neuronal System pathway
REACT_233318
Transmission across Chemical Synapses pathway
KEGG
mmu04742
Taste transduction pathway
mmu04930
Type II diabetes mellitus pathway
mmu04020
Calcium signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13685
Neuronal System pathway
REACT_13606
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04742
Taste transduction pathway
hsa04930
Type II diabetes mellitus pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A2AIR7
UniProt Splice Variant
Entrez Gene 12287
UniGene Mm.397878 Mm.4424
RefSeq NM_001042528 NM_007579 XM_006497631 XM_006497632 XM_006497633 XM_006497634
OMIM
CCDS CCDS15739 CCDS38065
HPRD
IMGT
MGI ID MGI:88296
MGI Symbol Cacna1b
EMBL AL732525 AL732546 BX294112
GenPept
RNA Seq Atlas 12287

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca