InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GAPDH

Summary

InnateDB Gene

IDBG-14270.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAPDH

Gene Name

glyceraldehyde-3-phosphate dehydrogenase

Synonyms

G3PD; GAPD; HEL-S-162eP

Species

Homo sapiens

Ensembl Gene

ENSG00000111640

Encoded Proteins

IDBP-14272

glyceraldehyde-3-phosphate dehydrogenase

IDBP-236487

glyceraldehyde-3-phosphate dehydrogenase

IDBP-236489

glyceraldehyde-3-phosphate dehydrogenase

IDBP-236491

glyceraldehyde-3-phosphate dehydrogenase

IDBP-236493

glyceraldehyde-3-phosphate dehydrogenase

IDBP-807370

glyceraldehyde-3-phosphate dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:6533927-6538374

Strand

Forward strand

Band

p13.31

Transcripts

ENST00000229239	ENSP00000229239
ENST00000396861	ENSP00000380070
ENST00000396859	ENSP00000380068
ENST00000396858	ENSP00000380067
ENST00000396856	ENSP00000380065
ENST00000496049
ENST00000492719
ENST00000474249
ENST00000466588
ENST00000466525
ENST00000619601	ENSP00000478864

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 232 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	232 [view]
Protein-Protein	216 [view]
Protein-DNA	10 [view]
Protein-RNA	6 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0035605	peptidyl-cysteine S-nitrosylase activity
GO:0042802	identical protein binding
GO:0050661	NADP binding
GO:0051287	NAD binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0017148	negative regulation of translation
GO:0035606	peptidyl-cysteine S-trans-nitrosylation
GO:0044281	small molecule metabolic process
GO:0050821	protein stabilization
GO:0051402	neuron apoptotic process
GO:0055114	oxidation-reduction process
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0097452	GAIT complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000078965

View Gene Order

ENSBTAG00000014731

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_1383

Glycolysis pathway

REACT_1520

Gluconeogenesis pathway

REACT_200783

Myoclonic epilepsy of Lafora pathway

REACT_474

Metabolism of carbohydrates pathway

REACT_111217

Metabolism pathway

REACT_116125

Disease pathway

REACT_723

Glucose metabolism pathway

REACT_200833

Glycogen storage diseases pathway

KEGG

hsa00010

Glycolysis / Gluconeogenesis pathway

hsa05010

Alzheimer's disease pathway

INOH

INOH website

Glycolysis Gluconeogenesis pathway

PID NCI

myc_activpathway

Validated targets of C-MYC transcriptional activation

Cross-References

SwissProt

P04406

TrEMBL

A4UCT1 G9BZK0 K4EN11 Q0QET7 Q5ZEY3 V9HVZ4

UniProt Splice Variant

Entrez Gene

2597

UniGene

Hs.592355

RefSeq

NM_002046 NM_001256799 NM_001289745 NM_001289746

HUGO

HGNC:4141

OMIM

138400

CCDS

CCDS8549 CCDS58201

HPRD

00713

IMGT

EMBL

AB062273 AC006064 AF261085 AJ844645 AY007133 AY340484 BC001601 BC004109 BC009081 BC013310 BC023632 BC025925 BC026907 BC029618 BC083511 BT006893 CH471116 CR407671 DQ403057 EF036498 EU668321 HQ727992 J02642 J04038 JN613427 JN613428 JN613429 M17851 M33197 X01677 X53778

GenPept

AAA52496 AAA52518 AAA53191 AAA86283 AAF99678 AAG01996 AAH01601 AAH04109 AAH09081 AAH13310 AAH23632 AAH25925 AAH26907 AAH29618 AAH83511 AAP35539 AAP88932 ABD77190 ABO65084 ACF94474 AEQ28035 AEQ28036 AEQ28037 AET97565 BAB93466 CAA25833 CAA37794 CAG28599 CAH59756 EAW88787

RNA Seq Atlas

2597