InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Serpinb9

Summary

InnateDB Gene

IDBG-142836.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpinb9

Gene Name

serine (or cysteine) peptidase inhibitor, clade B, member 9

Synonyms

BB283241; CAP-3; CAP3; ovalbumin; PI-9; PI9; Spi6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000045827

Encoded Proteins

IDBP-137038

serine (or cysteine) peptidase inhibitor, clade B, member 9

IDBP-142838

serine (or cysteine) peptidase inhibitor, clade B, member 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22167597

Serpinb9 expression in tubular epithelial cells (TECs) is induced by triggering of the viral double-stranded RNA sensors Tlr3, Ifih1 and Ddx58. Serpinb9 upregulation increases the threshold for granzyme B-mediated apoptosis in TECs and protects the kidney against cytotoxic insults during viral infection. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 22167597

[Homo sapiens] SERPINB9 expression in human tubular epithelial cells (TECs) is induced by triggering of the viral double-stranded RNA sensors TLR3, IFIH1 and DDX58. SERPINB9 upregulation increases the threshold for granzyme B-mediated apoptosis in TECs and protects the kidney against cytotoxic insults during viral infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170542:
This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:33003250-33017957

Strand

Forward strand

Band

A3.2

Transcripts

ENSMUST00000063191	ENSMUSP00000099002
ENSMUST00000006391	ENSMUSP00000006391

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0001913	T cell mediated cytotoxicity
GO:0002438	acute inflammatory response to antigenic stimulus
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0042742	defense response to bacterium
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0070233	negative regulation of T cell apoptotic process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000170542

View Gene Order

ENSBTAG00000031267

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05146

Amoebiasis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05146

Amoebiasis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

O08797

UniProt Splice Variant

Entrez Gene

20723

UniGene

Mm.272569 Mm.459547 Mm.466441

RefSeq

NM_009256 XM_006516625 XM_006516626 XM_006516627 XM_006516628 XM_006516629

OMIM

CCDS

CCDS26431

HPRD

IMGT

MGI ID

MGI:106603

MGI Symbol

Serpinb9

EMBL

AK035624 AK161581 AL589871 BC029900 CH466561 U96700

GenPept

AAB57812 AAH29900 BAC29128 BAE36475 EDL32351

RNA Seq Atlas

20723