InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prkcd

Summary

InnateDB Gene

IDBG-142854.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prkcd

Gene Name

protein kinase C, delta

Synonyms

AI385711; D14Ertd420e; PKC[d]; Pkcd; PKCdelta

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021948

Encoded Proteins

IDBP-142856

protein kinase C, delta

IDBP-256467

protein kinase C, delta

IDBP-256469

protein kinase C, delta

IDBP-256471

protein kinase C, delta

IDBP-256473

protein kinase C, delta

IDBP-256475

protein kinase C, delta

IDBP-256479

protein kinase C, delta

IDBP-256481

protein kinase C, delta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22265677

Prkcd is an essential signalling kinase in C-type lectin receptor-mediated innate immunity and host protection.

PMID 23326354

Suppression of Prkcd expression inhibited nitric oxide production in activated macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 19150425

[Homo sapiens] Following TNF stimulation, PRKCD phosphorylates TRAF2 leading to CHUK (IKK alpha) and IKBKB (IKK beta) recruitment to the TNF receptor

PMID 22265677

[Homo sapiens] PRKCD is an essential signalling kinase in C-type lectin receptor-mediated innate immunity and host protection. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163932:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:30595356-30626210

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022521	ENSMUSP00000022521
ENSMUST00000112211	ENSMUSP00000107830
ENSMUST00000112210	ENSMUSP00000107829
ENSMUST00000112208	ENSMUSP00000107827
ENSMUST00000112207	ENSMUSP00000107826
ENSMUST00000112206	ENSMUSP00000107825
ENSMUST00000112203	ENSMUSP00000107822
ENSMUST00000112202	ENSMUSP00000107821
ENSMUST00000140701
ENSMUST00000130736
ENSMUST00000128135
ENSMUST00000145806
ENSMUST00000135714

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008047	enzyme activator activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0043560	insulin receptor substrate binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0016064	immunoglobulin mediated immune response
GO:0018107	peptidyl-threonine phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0023021	termination of signal transduction
GO:0030837	negative regulation of actin filament polymerization
GO:0032613	interleukin-10 production
GO:0032615	interleukin-12 production
GO:0032930	positive regulation of superoxide anion generation
GO:0034351	negative regulation of glial cell apoptotic process
GO:0035307	positive regulation of protein dephosphorylation
GO:0035556	intracellular signal transduction
GO:0042100	B cell proliferation
GO:0042119	neutrophil activation
GO:0042742	defense response to bacterium
GO:0043085	positive regulation of catalytic activity
GO:0043407	negative regulation of MAP kinase activity
GO:0045087	innate immune response (InnateDB)
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0051490	negative regulation of filopodium assembly
GO:0090331	negative regulation of platelet aggregation
GO:0090398	cellular senescence
GO:1900163	positive regulation of phospholipid scramblase activity
GO:2000304	positive regulation of ceramide biosynthetic process
GO:2000753	positive regulation of glucosylceramide catabolic process
GO:2000755	positive regulation of sphingomyelin catabolic process
GO:2001022	positive regulation of response to DNA damage stimulus
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000163932

View Gene Order

ENSBTAG00000008719

Not yet available

Pathways

NETPATH

REACTOME

REACT_239142

Innate Immune System pathway

REACT_258521

Apoptosis pathway

REACT_188191

Signaling by ERBB2 pathway

REACT_188190

PLCG1 events in ERBB2 signaling pathway

REACT_223625

GPCR downstream signaling pathway

REACT_189085

Disease pathway

REACT_224553

Hemostasis pathway

REACT_254215

Signaling by GPCR pathway

REACT_210240

Role of phospholipids in phagocytosis pathway

REACT_198687

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_259326

Ca-dependent events pathway

REACT_227951

Signaling by VEGF pathway

REACT_188177

Signaling by FGFR in disease pathway

REACT_188573

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_233584

Cytokine Signaling in Immune system pathway

REACT_198691

HuR stabilizes mRNA pathway

REACT_245086

VEGFR2 mediated cell proliferation pathway

REACT_224460

Apoptotic cleavage of cellular proteins pathway

REACT_263607

PLC-gamma1 signalling pathway

REACT_230745

Immune System pathway

REACT_224879

Platelet activation, signaling and aggregation pathway

REACT_236516

EGFR interacts with phospholipase C-gamma pathway

REACT_230639

Downstream signal transduction pathway

REACT_231729

Downstream signaling of activated FGFR pathway

REACT_240702

CaM pathway pathway

REACT_219232

Effects of PIP2 hydrolysis pathway

REACT_242976

Signaling by EGFR pathway

REACT_258013

G alpha (z) signalling events pathway

REACT_198660

Interferon gamma signaling pathway

REACT_198666

Interferon Signaling pathway

REACT_230708

Phospholipase C-mediated cascade pathway

REACT_257088

VEGFA-VEGFR2 Pathway pathway

REACT_209368

Fcgamma receptor (FCGR) dependent phagocytosis pathway

REACT_248921

Signalling by NGF pathway

REACT_233572

Gene Expression pathway

REACT_263353

Signaling by PDGF pathway

REACT_188269

DAG and IP3 signaling pathway

REACT_237883

NGF signalling via TRKA from the plasma membrane pathway

REACT_207651

G alpha (q) signalling events pathway

REACT_242845

Opioid Signalling pathway

REACT_215587

Calmodulin induced events pathway

REACT_188257

Signal Transduction pathway

REACT_242456

Signaling by FGFR pathway

REACT_253342

PLC beta mediated events pathway

REACT_248370

G-protein mediated events pathway

REACT_188180

Signaling by EGFR in Cancer pathway

REACT_207035

Apoptotic execution phase pathway

REACT_188188

DAP12 interactions pathway

REACT_188185

DAP12 signaling pathway

KEGG

mmu04530

Tight junction pathway

mmu04930

Type II diabetes mellitus pathway

mmu04664

Fc epsilon RI signaling pathway pathway

mmu04912

GnRH signaling pathway pathway

mmu04666

Fc gamma R-mediated phagocytosis pathway

mmu04062

Chemokine signaling pathway pathway

mmu04270

Vascular smooth muscle contraction pathway

mmu04722

Neurotrophin signaling pathway pathway

INOH