Version 5.4
Mus musculus Gene: Itih4
Summary
InnateDB Gene IDBG-143373.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itih4
Gene Name inter alpha-trypsin inhibitor, heavy chain 4
Synonyms ITI-HC4; Itih-4
Species Mus musculus
Ensembl Gene ENSMUSG00000021922
Encoded Proteins
IDBP-143375
inter alpha-trypsin inhibitor, heavy chain 4
IDBP-143377
inter alpha-trypsin inhibitor, heavy chain 4
IDBP-401579
inter alpha-trypsin inhibitor, heavy chain 4
IDBP-624411
inter alpha-trypsin inhibitor, heavy chain 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000055955:
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:30886476-30901981
Strand Forward strand
Band B
Transcripts
ENSMUST00000006703 ENSMUSP00000006703
ENSMUST00000078490 ENSMUSP00000077580
ENSMUST00000120269 ENSMUSP00000112798
ENSMUST00000134988
ENSMUST00000168782 ENSMUSP00000125920
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0006953 acute-phase response
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
GO:0034097 response to cytokine
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000055955
View Gene Order
ENSBTAG00000007850
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.34819 Mm.415981
RefSeq NM_001159299 NM_001289632 NM_001289633 NM_018746 XM_006518589
OMIM
CCDS CCDS26901 CCDS49433 CCDS70558
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca